Many of you have asked, so here’s what’s going on with me.
WHAT HAPPENED BEFORE
- 8/1979: Born. Grew up in CT, built a killer eraser collection, fell in love with computers.
- Left college to start a company. Fell hard. Fled to India for 3 months.
- Started 2nd company. Learned to be an adult. Fell in love with NYC.
- Moved to SF, discovered burritos & some of my fave people on Earth.
- 9/2011: Got diagnosed with Leukemia!
- Cried. Went through 3 cycles of chemo. Hurt. Thought hard about what I want out of life. Grew up a second time.
TODAY
… After over 100 drives organized by friends, family, and strangers, celebrity call-outs, a bazillion reblogs (7000+!), tweets, and Facebook posts, press, fundraising and international drives organized by tireless friends, and a couple painful false starts, I’ve got a 10/10 matched donor!
You all literally helped save my life. (And the lives of many others.)
WHAT HAPPENS NEXT
Tomorrow, I’ll be admitted to Dana Farber in Boston for 4-5 weeks.
First I’ll get a second Hickman line to allow direct access to my heart (for meds and for nutrients if I’m not able to eat). Over the next week, the docs blast my body with a stiff chemo cocktail to try and eradicate all traces of cancer cells. In the process, the immune system I was born with, and my body’s ability to make blood, are destroyed.
Next Friday, I get my donor’s stem cells by IV. I start on immunosuppressants to prevent my body from rejecting them (I’ll be on them for 12-18 months). For these weeks I’ve no immune system, so I’m severely vulnerable to viruses and bacteria. My hospital room and hallway become my world.
Meanwhile, the stem cells make their way to my bone marrow and, with some luck, start producing platelets, red blood cells, and white blood cells. At this point, my blood type changes to the blood type of my donor. And my blood will now have my donor’s DNA, not my own.
This is science fiction stuff. I can hardly believe it’s even possible, and there’s lots of chances for things to go wrong. It’s frightening.
AFTER THE TRANSPLANT
Recovery to a new state of “normal” takes about a year, but there’s a few storm clouds hovering:
- My immune system is new, like a baby’s. I’m prone to getting sick.
- Just as with any organ transplant, there’s a chance of rejection. Except in this case, it’s my blood that’s the foreign body, and it touches every organ. They call it graft-vs-host-disease and it can cause health issues and organ complications for the rest of my life.
- Successful transplant or not, Leukemia can relapse. Stubborn mofo.
Overall, 75% of AML transplant patients survive year one, 50% make it through year five. My odds are a little better since I’m young.
THE GREAT NEWS
I’ve got a long road ahead. But I’ve got a donor & amazing family & friends. A few months ago I didn’t have many options. Today I have a plan.
I am alive. I start tomorrow. Wish me luck!
Thank you.
Go internet!
Source: superamit
Android phones aren’t as simple to use as the iPhone, but they’re not that much more complicated, and “if you’re willing to do the work to understand it a little bit, well I hate to say it, but there’s more available in some ways.
Woz often diverged from Jobs. He wanted Macs to be easily upgradable, Jobs didn’t. Same reason he likes Android.
One of the things that drove Jobs nuts was how he thought Google stabbed him in the back with Android, he felt they stole a lot of the iPhone technology from him and would not get into the smartphone business, even at just the OS level. This comment from Woz would have likely set him off if he were still around today because of the anger he carried around with him about Google.
(via soupsoup)
It’s also worth pointing out that to the vast majority of people out there, the notion that they have to “work” at their phone is fairly objectionable. Some people like to tinker on cars. Most want a car that “just works.”
(via rickwebb)
Not at iPhone prices though. Not necessarily Android prices either. None of my friends in MI have either; they have a flip phone or maybe a touchscreen and they are teachers or salon owners or bankers (in a small town) etc. And all their phones ‘just work’ for what they use them for.
(via rickwebb)
Source: soupsoup
![jtotheizzoe:
the-star-stuff:
The best Celestial Events to expect in 2012
2012 is here, what celestial events might we look forward to seeing?
Jan. 4: Quadrantid meteor shower peaks
This meteor shower reaches its peak in the predawn hours of Jan. 4 for eastern North America. The Quadrantid meteor shower is a very short-lived meteor display, whose peak rates only last several hours. The phase of the moon is a bright waxing gibbous, normally prohibitive for viewing any meteor shower, but the moon will set by 3 a.m., leaving the sky dark for a few hours until the first light of dawn; that’s when you’ll have the best shot at seeing many of these bluish-hued meteors.
From the eastern half of North America, a single observer might count on seeing as many as 50-to-100 “Quads” in a single hour. From the western half of the continent the display will be on the wane by the time the moon sets, with hourly rates probably diminishing to around 25 to 50 meteors.
Feb. 20 to March 12: Best evening apparition of Mercury
In February and March, the “elusive” innermost planet Mercury moves far enough from the glare of the sun to be readily visible soon after sunset. Its appearance will be augmented by two other bright planets (Venus and Jupiter), which also will be visible in the western sky during this same time frame.
Mercury will arrive at its greatest elongation from the sun March 5. It will be quite bright (-1.3-to-0 magnitude) before this date and will fade rapidly to +1.6 magnitude thereafter. Astronomers measure the brightness of objects in terms of magnitude, with lower numbers corresponding to brighter objects.
March 3: Mars arrives at opposition
On March 3, the Earth will be passing Mars as the two planets wheel around the sun in their respective orbits. Because Mars reaches aphelion — its farthest point from the sun — on Feb. 15, this particular opposition will be an unfavorable one. In fact, two days after opposition, Mars will be closest to Earth at a distance of 62.6 million miles.
Compare this with the August 2003 opposition when Mars was only 34.6 million miles away. Nonetheless, even at this unfavorable opposition the fiery-hued Mars will be an imposing naked-eye sight, shining at magnitude -1.2, just a bit dimmer than Sirius, the brightest star, and will be visible in the sky all night long.
March 13: Brilliant “double planet”
The two brightest planets, Venus and Jupiter, team up to make for an eye-catching sight in the western sky soon after sunset. They will be separated by 3 degrees on this evening, Venus passing to the northwest (upper right) of Jupiter and shining nearly eight times brighter than “Big Jupe.” Although they will gradually go their separate ways after this date, on March 25 and 26, a crescent moon will pass by, adding additional beauty to this celestial scene.
May 5: Biggest full moon of 2012
The moon turns full at 11:35 p.m. Eastern Daylight Time and just 25 minutes later it will arrive at its closest point to the Earth in 2012, at a distance of 221,801 miles. Expect a large range in ocean tides (exceptionally low to exceptionally high) for the next few days. [Photos: ‘Supermoon’ of 2011]
May 20: Annular eclipse of the sun
The path of annularity for this eclipse starts over eastern China and sweeps northeast across southern and central Japan. The path continues northeast then east, passing just south of Alaska’s Aleutian Island chain. The path then turns to the southeast, making landfall in the western United States along the California-Oregon coast. It will pass over central Nevada, southern Utah, northern Arizona, the extreme southwest corner of Colorado and most of New Mexico before coming to an end over northern Texas.
Since the disk of the moon will appear smaller than the disk of the sun, it will create a “penny on nickel” effect, with a fiery ring of sunlight shining around the moon’s dark silhouette. Locations that will witness this eerie sight include Eureka and Reading, Calif.; Carson City, Reno and Ely, Nev.; Bryce Canyon in Utah; Arizona’s Grand Canyon; Albuquerque and Santa Fe in New Mexico and just prior to sunset for Lubbock, Tex.
A partial eclipse of the sun will be visible over a large swath of the United States and Canada, including Alaska and Hawaii, but no eclipse will be visible near and along the Atlantic Seaboard.
June 4: Partial eclipse of the moon
This partial lunar eclipse favors the Pacific Ocean; Hawaii sees it high in the sky during the middle of its night. Across North America the eclipse takes place between midnight and dawn. The farther east one goes, the closer the time of moonset coincides with the moment that the moon enters the Earth’s dark umbral shadow.
In fact, over the Northeastern United States and eastern Canada, the only evidence of this eclipse will be a slight shading on the moon’s left edge (the faint penumbral shadow) before moonset. Over the Canadian Maritimes, the moon will set before the eclipse begins. At maximum, more than one-third of the moon’s lower portion (37.6-percent) will be immersed in the umbra.
June 5: Rare transit of Venus across the sun
The passage of Venus in front of the sun is among the rarest of astronomical events, rarer even than the return of Halley’s Comet every 76 years. Only six transits of Venus are known to have been observed by humans before: in 1639, 1761, 1769, 1874, 1882 and, most recently, in 2004.
The next one will occur in the year 2117. When Venus is in transit across the solar disk, the planet appears as a distinct, albeit tiny, round black spot with a diameter just 1/32nd of the sun. This size is large enough to readily perceive with the naked eye. HOWEVER … prospective observers are warned to take special precautions (as with a solar eclipse) when attempting to view the silhouette of Venus against the blindingly brilliant solar disc.
The beginning of the transit will be visible from all of North America, Greenland, extreme northern and western portions of South America, Hawaii, northern and eastern portions of Asia including Japan, New Guinea, northern and eastern portions of Australia, and New Zealand. The end will be visible over Alaska, all of Asia and Indonesia, Australia, Eastern Europe, the eastern third of Africa, and the island nation of Madagascar.
Aug. 12: Perseid meteor shower
Considered to be among the best of the annual displays thanks to its high rates of up to 90 per hour for a single observer, as well as its reliability. Beloved by summer campers and often discovered by city dwellers who might be spending time in the country under dark starry skies. [10 Perseid Meteor Shower Facts]
Last summer a bright moon wrecked the shower by blotting out many of the fainter streaks, but in 2012 the moon will be three days past last quarter phase on this peak morning – a fat waning crescent presenting only a minor nuisance for prospective observers.
Nov. 13: Total eclipse of the sun
The first total solar eclipse since July 2010. Virtually the entire path of totality falls over water. At the very beginning, the track cuts through Australia’s Northern Territory just to the east of Darwin, then across the Gulf of Carpentaria, then through northern Queensland, passing over Cairns and Port Douglas before heading out to sea.
The rest of the eclipse path, including the point of the maximum duration of totality (4 minutes, 2 seconds) is, unfortunately, pretty much wasted by falling over the open waters of the Pacific Ocean.
Dec. 13-14: Geminid meteor shower
If there is one meteor display guaranteed to put on a very entertaining show it is the Geminid meteor shower. Now considered by most meteor experts to be at the top of the list, surpassing in brilliance and reliability even the August Perseids.
Bundle warmly against the winter chill; you can start observing as soon as darkness falls on the evening of Dec. 13 as Gemini starts coming up above the eastern horizon and continue through the rest of the night. Around 2 a.m. when Gemini is almost directly overhead, you might see as many as two meteor sightings per minute … 120 per hour! And the moon is new, meaning that it will not be a factor at all.
Dec. 25: Christmas evening and Jupiter
On Christmas, many will be looking skyward and wondering what that brilliant silvery “star” is hovering just above the waxing gibbous moon. It’s not a star (or Santa returning to the North Pole), but the largest planet in our solar system, Jupiter, serving as a sort of holiday ornament with our nearest neighbor in space to cap off a year of interesting and predictable sky events that we all can enjoy!
(Submitted by vernardm)
I’ll go ahead and add this for the submitter, vernardm, who has mastered the use of Ctrl+C: This material was originally posted by Joe Rao of Space.com/Scientific American
I’m looking forward to several of ‘em, though. Every year is a good year to look up and pay attention, 2012 will be no exception.](http://www.tumblr.com/photo/1280/lauraglu/15228659002/1/tumblr_lx7bp5zC3B1qe649z)
The best Celestial Events to expect in 2012
2012 is here, what celestial events might we look forward to seeing?
Jan. 4: Quadrantid meteor shower peaks
This meteor shower reaches its peak in the predawn hours of Jan. 4 for eastern North America. The Quadrantid meteor shower is a very short-lived meteor display, whose peak rates only last several hours. The phase of the moon is a bright waxing gibbous, normally prohibitive for viewing any meteor shower, but the moon will set by 3 a.m., leaving the sky dark for a few hours until the first light of dawn; that’s when you’ll have the best shot at seeing many of these bluish-hued meteors.
From the eastern half of North America, a single observer might count on seeing as many as 50-to-100 “Quads” in a single hour. From the western half of the continent the display will be on the wane by the time the moon sets, with hourly rates probably diminishing to around 25 to 50 meteors.
Feb. 20 to March 12: Best evening apparition of Mercury
In February and March, the “elusive” innermost planet Mercury moves far enough from the glare of the sun to be readily visible soon after sunset. Its appearance will be augmented by two other bright planets (Venus and Jupiter), which also will be visible in the western sky during this same time frame.
Mercury will arrive at its greatest elongation from the sun March 5. It will be quite bright (-1.3-to-0 magnitude) before this date and will fade rapidly to +1.6 magnitude thereafter. Astronomers measure the brightness of objects in terms of magnitude, with lower numbers corresponding to brighter objects.
March 3: Mars arrives at opposition
On March 3, the Earth will be passing Mars as the two planets wheel around the sun in their respective orbits. Because Mars reaches aphelion — its farthest point from the sun — on Feb. 15, this particular opposition will be an unfavorable one. In fact, two days after opposition, Mars will be closest to Earth at a distance of 62.6 million miles.
Compare this with the August 2003 opposition when Mars was only 34.6 million miles away. Nonetheless, even at this unfavorable opposition the fiery-hued Mars will be an imposing naked-eye sight, shining at magnitude -1.2, just a bit dimmer than Sirius, the brightest star, and will be visible in the sky all night long.
March 13: Brilliant “double planet”
The two brightest planets, Venus and Jupiter, team up to make for an eye-catching sight in the western sky soon after sunset. They will be separated by 3 degrees on this evening, Venus passing to the northwest (upper right) of Jupiter and shining nearly eight times brighter than “Big Jupe.” Although they will gradually go their separate ways after this date, on March 25 and 26, a crescent moon will pass by, adding additional beauty to this celestial scene.
May 5: Biggest full moon of 2012
The moon turns full at 11:35 p.m. Eastern Daylight Time and just 25 minutes later it will arrive at its closest point to the Earth in 2012, at a distance of 221,801 miles. Expect a large range in ocean tides (exceptionally low to exceptionally high) for the next few days. [Photos: ‘Supermoon’ of 2011]
May 20: Annular eclipse of the sun
The path of annularity for this eclipse starts over eastern China and sweeps northeast across southern and central Japan. The path continues northeast then east, passing just south of Alaska’s Aleutian Island chain. The path then turns to the southeast, making landfall in the western United States along the California-Oregon coast. It will pass over central Nevada, southern Utah, northern Arizona, the extreme southwest corner of Colorado and most of New Mexico before coming to an end over northern Texas.
Since the disk of the moon will appear smaller than the disk of the sun, it will create a “penny on nickel” effect, with a fiery ring of sunlight shining around the moon’s dark silhouette. Locations that will witness this eerie sight include Eureka and Reading, Calif.; Carson City, Reno and Ely, Nev.; Bryce Canyon in Utah; Arizona’s Grand Canyon; Albuquerque and Santa Fe in New Mexico and just prior to sunset for Lubbock, Tex.
A partial eclipse of the sun will be visible over a large swath of the United States and Canada, including Alaska and Hawaii, but no eclipse will be visible near and along the Atlantic Seaboard.
June 4: Partial eclipse of the moon
This partial lunar eclipse favors the Pacific Ocean; Hawaii sees it high in the sky during the middle of its night. Across North America the eclipse takes place between midnight and dawn. The farther east one goes, the closer the time of moonset coincides with the moment that the moon enters the Earth’s dark umbral shadow.
In fact, over the Northeastern United States and eastern Canada, the only evidence of this eclipse will be a slight shading on the moon’s left edge (the faint penumbral shadow) before moonset. Over the Canadian Maritimes, the moon will set before the eclipse begins. At maximum, more than one-third of the moon’s lower portion (37.6-percent) will be immersed in the umbra.
June 5: Rare transit of Venus across the sun
The passage of Venus in front of the sun is among the rarest of astronomical events, rarer even than the return of Halley’s Comet every 76 years. Only six transits of Venus are known to have been observed by humans before: in 1639, 1761, 1769, 1874, 1882 and, most recently, in 2004.
The next one will occur in the year 2117. When Venus is in transit across the solar disk, the planet appears as a distinct, albeit tiny, round black spot with a diameter just 1/32nd of the sun. This size is large enough to readily perceive with the naked eye. HOWEVER … prospective observers are warned to take special precautions (as with a solar eclipse) when attempting to view the silhouette of Venus against the blindingly brilliant solar disc.
The beginning of the transit will be visible from all of North America, Greenland, extreme northern and western portions of South America, Hawaii, northern and eastern portions of Asia including Japan, New Guinea, northern and eastern portions of Australia, and New Zealand. The end will be visible over Alaska, all of Asia and Indonesia, Australia, Eastern Europe, the eastern third of Africa, and the island nation of Madagascar.
Aug. 12: Perseid meteor shower
Considered to be among the best of the annual displays thanks to its high rates of up to 90 per hour for a single observer, as well as its reliability. Beloved by summer campers and often discovered by city dwellers who might be spending time in the country under dark starry skies. [10 Perseid Meteor Shower Facts]
Last summer a bright moon wrecked the shower by blotting out many of the fainter streaks, but in 2012 the moon will be three days past last quarter phase on this peak morning – a fat waning crescent presenting only a minor nuisance for prospective observers.
Nov. 13: Total eclipse of the sun
The first total solar eclipse since July 2010. Virtually the entire path of totality falls over water. At the very beginning, the track cuts through Australia’s Northern Territory just to the east of Darwin, then across the Gulf of Carpentaria, then through northern Queensland, passing over Cairns and Port Douglas before heading out to sea.
The rest of the eclipse path, including the point of the maximum duration of totality (4 minutes, 2 seconds) is, unfortunately, pretty much wasted by falling over the open waters of the Pacific Ocean.
Dec. 13-14: Geminid meteor shower
If there is one meteor display guaranteed to put on a very entertaining show it is the Geminid meteor shower. Now considered by most meteor experts to be at the top of the list, surpassing in brilliance and reliability even the August Perseids.
Bundle warmly against the winter chill; you can start observing as soon as darkness falls on the evening of Dec. 13 as Gemini starts coming up above the eastern horizon and continue through the rest of the night. Around 2 a.m. when Gemini is almost directly overhead, you might see as many as two meteor sightings per minute … 120 per hour! And the moon is new, meaning that it will not be a factor at all.
Dec. 25: Christmas evening and Jupiter
On Christmas, many will be looking skyward and wondering what that brilliant silvery “star” is hovering just above the waxing gibbous moon. It’s not a star (or Santa returning to the North Pole), but the largest planet in our solar system, Jupiter, serving as a sort of holiday ornament with our nearest neighbor in space to cap off a year of interesting and predictable sky events that we all can enjoy!
(Submitted by vernardm)
I’ll go ahead and add this for the submitter, vernardm, who has mastered the use of Ctrl+C: This material was originally posted by Joe Rao of Space.com/Scientific American
I’m looking forward to several of ‘em, though. Every year is a good year to look up and pay attention, 2012 will be no exception.
Source: the-star-stuff
So, this enterprising fellow fills ornaments with stuff (dye, coloured sand, gelatin, cake sprinkles), shoots them, and photographs the results. It’s good to have hobbies.
GOOD ENOUGH
Art!
Source: birdlord
We call it the ‘product launch’ when you put the product in front of customers — and you should do that as soon as possible — but do the marketing launch — when you’re pounding your chest and talking about how great you are — as late as possible.
Eric Reis
this is good advice
Why you shouldn’t launch your startup in the press — Tech News and Analysis
(via fred-wilson)
(via fred-wilson)
Source: gigaom.com
Hellman said he came to view money “like manure. If you spread it around, good things will grow — and if you pile it up, it just smells bad,” he told Forbes.com.
Through the lens, let’s journey through time.
Another entry for Friday’s Amazing Journeys. In the early morning hours of April 18, 1906, San Francisco was shaken by a massive and legendary earthquake. The quake and resulting fire decimated the city, killing as many as 3,000.
A few weeks after the quake, George Lawrence took the iconic photograph pictured above (top). The aerial panorama shows the true extent of the damage, and it’s darkly fascinating. Click here (do it) to find an embiggened version, to explore down to the pixel, almost to the individual face.
Of course, airplanes weren’t even three years old by this time, so aerial photography techniques were quite different than they are today. Airships were expensive and hard to control, so how did Lawrence do it?
Kites.
That’s quite the setup. Cameras weren’t exactly available off the shelf, either, so Lawrence had to build his own!
A century later, a group of photographers and tinkerers led by Ron Klein wanted to recreate the picture, using modern San Francisco as a backdrop. They built a modern version of Lawrence’s camera, attached it to a helicopter, and the result is the bottom version up there.
And of course, this journey wouldn’t be complete without an equally embiggened version of Klein’s feat, too.
Who says you need a time machine?
(images via Ron Klein Photography and USGS, hi-res photo 1 and photo 2)
So cool.
Source: jtotheizzoe
The four fallacies of metrics
- There are, it turns out, four different ways to do metrics wrong. You can: Measure the right things badly.
- Measure the wrong things, either well or badly.
- Neglect to measure something important.
- Extend measures to individual employees.
Source: infoworld.com
I had seen a clip of this Romney encounter on TV a few times, but seeing the full version here, including the man’s comments after Romney leaves, really tells the full story.
It is fascinating to watch politicians have to look gay people in the eye as they advocate for their inequality. The abstract “gay” is very different from the gay veteran sitting at a diner with his husband, or a lesbian mother showing off her ridiculously cute daughters in the face of a mayor who made a derogatory statement about “queers” on Facebook.
It is really starting to feel like the politics have changed so much since 2004. If marriage equality becomes a major issue in 2012, I think it’s actually going to be a really bad thing for Republicans. Though Obama better keep “evolving” if he’s going to be on the right side of history.
This vet gives a master class on having a conversation with a politician to whom you are diametrically opposed. I will admit I’ve wondered sometimes what I would do if I were ever in a position to meet, say, George W Bush, in the same way I have a vague mental protocol for a grizzly bear encounter or shark attack.
Source: chriskelly
